The findings are drawn largely from trials conducted in the USA, Western Europe and Australasia, and so relate most directly to the healthcare systems and treatments available in these countries. More research is needed on the development and delivery of such treatment approaches in other parts of the world.
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| Strength of Evidence |
Each key finding has been rated according the strength of evidence supporting it.
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 | Multiple well-designed randomized clinical trials yielded a consistent pattern of findings. |
 | Some evidence from randomized clinical trials but the scientific support was not optimal. |
 | Limited evidence indicative of a possible effect but not sufficient to support a recommendation. |
