- Safety of nicotine and other medications to aid smoking cessation in pregnant smokers, including impact on the health and development of newborns of mothers who received medication during pregnancy.
- Safety of bupropion in high risk groups (hypertension or other cardiovascular disease, pregnancy, alcohol abuse, history of stroke or other brain injury).
- Safety of combinations of nicotine replacement therapies or combination of nicotine replacement therapy and non-nicotine pharmacotherapies.
- Safety of nicotine and other medications to aid smoking cessation in adolescents.
- Health effects of novel nicotine delivery devices, including potential for use to initiate smoking (in adolescents) and potential adverse effects on smoking cessation (i.e. switching instead of quitting).
- Development of biomarkers of exposure and surrogate markers of health effects of tobacco and related products.
- Safety of long term nicotine replacement or other medication as would be used to reduce cigarette smoking or maintain tobacco abstinence.
- Abuse of nicotine products and delivery systems and other medications to aid smoking cessation in the over-the-counter setting (i.e. without physician oversight), including product initiation by adolescents and other non-smokers.
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