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All forms of NRT are similarly effective and the choice of type should be based on susceptibility to adverse effects, patient preference and availability.



There is no good evidence that one form of NRT is more efficacious than any other form (e.g. gum versus patch) when used at standard doses. In direct comparisons between gum, patch, nasal spray and inhalator, there were no short-term differences in abstinence rates or withdrawal discomfort.



Fiore MC, Jaén CR, Baker TB, et al. Treating Tobacco Use and Dependence: 2008 Update. Clinical Practice Guideline. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service. May 2008.

Stead LF, Perera R, Bullen C, Mant D, Hartmann-Boyce J, Cahill K, Lancaster T. Nicotine replacement therapy for smoking cessation. Cochrane Database of Systematic Reviews 2012, Issue 11. Art. No.: CD000146. DOI: 10.1002/14651858.CD000146.pub4.

Hajek P, West R, Foulds J, Nilsson F, Burrows D, Meadow A. Randomized comparative trial of nicotine polacrilex, a transdermal patch, nasal spray, and an inhaler. Arch Intern Med. 1999; 159: 2033-2038.

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