SRNT is the only international scientific society dedicated to fostering and disseminating research on tobacco and nicotine treatobacco.net logo Society for the Study of Addiction
Search treatobacco.net
* see translation disclaimer below
Some key links


Bupropion (Zyban) is an efficacious aid to smoking cessation.



Bupropion SR 150 has been shown to increase quit rates compared to placebo. Bupropion is likely to double the odds of long-term quitting. It is unclear whether bupropion has better efficacy than NRT, and whether the combination of bupropion and NRT increases quit rates over NRT or bupropion alone. The efficacy of bupropion is not due to its antidepressant effects; it works equally well in smokers with and without a history of depression. Doctors prescribing Zyban need to be aware of the contraindications to its use for people such as individuals with a history of a seizure disorder.

The choice between the use of NRT and bupropion is likely to depend on patient preference, contraindications, cost and availability. Where some NRT forms are available without prescription, smokers may choose to use these first.



Hughes JR, Stead LF, Hartmann-Boyce J, Cahill K, Lancaster T. Antidepressants for smoking cessation. Cochrane Database of Systematic Reviews 2014, Issue 1. Art. No.: CD000031. DOI: 10.1002/14651858.CD000031.pub4.

Fiore MC, Jaén CR, Baker TB, et al. Treating Tobacco Use and Dependence: 2008 Update. Clinical Practice Guideline. Rockville, MD: U.S. Department of Health and Human Services. Public Health Service. May 2008.

treatobacco.net logo
Home | Sitemap