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"Reduced risk" cigarettes including low tar cigarettes and novel tobacco products that deliver nicotine with minimal combustion of tobacco are promoted, implicitly or explicitly, to reduce the harm from smoking. None of these products have been determined to reduce the risk of cigarette smoking or to aid smoking cessation. Nicotine replacement therapy, bupropion, varenicline and other medications to aid smoking cessation are most likely safer than any "reduced risk" cigarette.



Low tar cigarettes have not been determined to reduce the health hazards of smoking, while they do provide adequate nicotine to sustain nicotine addiction (NCI monograph 13). Some cigarette brands, such as low-yield or 'light' brands, and some novel smoking devices, such as R.J. Reynolds’ 'Eclipse' and Phillip Morris' 'Accord' or Star Tobacco's reduced-nitrosamine cigarette (Omni), are suggested in promotional materials to be less hazardous than full-flavor regular cigarettes. Low-yield cigarettes are determined to be low-yield based on smoking machine testing. However, smokers do not smoke their cigarettes like the test machines, and smokers are easily able to get their desired dose of nicotine by smoking low-yield cigarettes more intensely, more frequently, and/or by covering ventilation holes over the filter (U.S. Department of Health and Human Services, 1996, NCI monograph 13). Research studies have shown that smokers of low-yield cigarettes take in similar levels of nicotine, carbon monoxide, and other tobacco smoke toxicants, compared to smokers of full-flavor cigarettes (Benowitz, 2001; NCI monograph 13; Hecht et al., 2005; Benowitz et al., 2005; Bernert et al., 2005; Blackford et al., 2006). Low-yield cigarettes have not been determined to substantially reduce the health hazards associated with cigarette smoking, and are not a good alternative to quitting.

Novel smoking products such as 'Eclipse' and 'Accord' are also promoted as less harmful.  These products are designed to heat rather than burn tobacco, with the expectation that lower levels of tobacco combustion products will be generated. In fact, there does appear to be some amount of burning of tobacco. Machine-determined yields of various oxidant gases and carcinogens appear to be lower with Eclipse compared to regular cigarettes. Machine testing of Eclipse using intensive smoking paradigms suggests that the yields of these toxins are similar to the yields of some ultra-low-yield cigarettes. Studies of 'Eclipse' smokers indicate that they get similar or higher levels of nicotine and carbon monoxide compared to when they are smoking regular cigarettes (Fagerström et al., 2000). One study suggested that 'Eclipse' exposes smokers to the inhalation of glass fibers, which could be carcinogenic (Pauly et al., 1998). Industry data suggest that an electrically-heated cigarette substitute (Accord) produces lower toxin delivery, but much more research is needed to assess risk (Buchhalter et al., 2000). The Omni cigarette is produced using tobacco with low nitrosamine content. However, tobacco smoke has many carcinogens in addition to nitrosamines. None of the novel smoking products has been demonstrated to reduce any health risks of smoking or to promote smoking cessation. Finally, some studies suggest that low yield cigarettes might reassure smokers that there is a safer way to smoke, thereby undermining the motivation to quit, with a negative public health impact (Giovino et al., 1996).

In contrast to these products, nicotine replacement therapy, bupropion, and varenicline have been extensively studied and shown to be safe in smokers. The latter are much preferred than novel tobacco products for reducing risk.



IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.

IARC Monographs Vol. 89 . Smokeless Tobacco and Some Tobacco-specific N-Nitrosamines. 2007. ISBN 978 92 832 1289 8.

Gartner CE, Hall WD, Vos T, Bertram MY, Wallace AL, Lim SS . Assessment of Swedish snus for tobacco harm reduction: an epidemiological modelling study. Lancet, 2007; 369: 2010-2014.

Hatsukami DK, Ebbert JO, Feuer RM, Stepanov I, Hecht SS . Changing smokeless tobacco products new tobacco-delivery systems. Am J Prev Med, 2007; 33(6 Suppl): S368-S78.

Kozlowski LT . Effect of smokeless tobacco product marketing and use on population harm from tobacco use policy perspective for tobacco-risk reduction. Am J Prev Med, 2007; 33(6 Suppl): S379-S386.

Martinet Y, Bohadana A, Fagerström K . Introducing oral tobacco for tobacco harm reduction: what are the main obstacles? Harm Reduct J, 2007; 4: 17.

Mendoza-Baumgart MI, Tulunay OE, Hecht SS, Zhang Y, Murphy S, Le C, Jensen J, Hatsukami DK . Pilot study on lower nitrosamine smokeless tobacco products compared with medicinal nicotine. Nicotine Tob Res, 2007; 9: 1309-1323.

Royal College of Physicians. Harm reduction in nicotine addiction. Helping people who can't quit. A report by the Tobacco Advisory Group of the Royal College of Physicians; 2007.

Stead LF, Lancaster T . Interventions to reduce harm from continued tobacco use. Cochrane Database Syst Rev, 2007; (3): CD005231.

Tomar SL . Epidemiologic perspectives on smokeless tobacco marketing and population harm. Am J Prev Med, 2007; 33(6 Suppl): S387-S397.

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans.

IARC Monographs Vol. 37 . Tobacco Habits other than Smoking; Betel-Quid and Areca-Nut Chewing; and some Related Nitrosamines. 1998. ISBN 92 832 1537 0.

U.S. Department of Health and Human Services . The Health Consequences of Using Smokeless Tobacco. A report of the Surgeon General. U.S. Department of Health and Human Services, Public Health Services, Office on smoking and health. NIH Publication No. 86-2874 , 1986.

Hecht SS . Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines. Chem Res Toxicol, 1998; 11: 559-603.

Stepanov I, Jensen J, Hatsukami D, Hecht SS. New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels. Nicotine Tob Res, submitted, 2007.

Hoffmann D, Djordjevic MV, Fan J, Zang E, Glynn T, Connolly GN . Five leading U.S. commercial brands of moist snuff in 1994 - Assessment of carcinogenic N-nitrosamines. J Natl Cancer Inst, 1995; 87: 1862-1869.

Osterdahl B-G. Occurrence of and exposure to N-nitrosamines in Sweden: a review. In Relevance to Human Cancer of N-Nitroso Compounds, Tobacco Smoke, and Mycotoxins, 1991; pp.235-237. Edited by IK O'Neill, JS Chen and H Bartsch. (not available on-line)

Stepanov I, Jensen J, Hatsukami D, Hecht SS . Tobacco-specific nitrosamines in new tobacco products. Nicotine Tobacco Res, 2006; 8: 309-313.

England LJ, Levine RJ, Mills JL, Klebanoff MA, Yu KF, Cnattingius S . Adverse pregnancy outcomes in snuff users. Am J Obstet Gynecol, 2003; 189: 939-943.

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